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KMID : 0923620210210020014
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Immune Network
2021 Volume.21 No. 2 p.14 ~ p.14
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Intranasal Vaccination with Outer-Membrane Protein of Orientia tsutsugamushi induces Protective Immunity Against Scrub Typhus
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Park Sung-Moo
Gu Min-Jeong
Ju Young-Jun
Cheon In-Su
Hwang Kyu-Jam
Gill Byoung-Chul
Shim Byoung-Shik
Jeong Hang-Jin
Son Young-Min
Choi Sang-Ho
Jeung Woon-Hee
Han Seung-Hyun
Chu Hyuk
Yun Cheol-Heui
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Abstract
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Scrub typhus develops after the individual is bitten by a trombiculid mite infected with Orientia tsutsugamushi. Since it has been reported that pneumonia is frequently observed in patients with scrub typhus, we investigated whether intranasal (i.n.) vaccination with the outer membrane protein of O. tsutsugamushi (OMPOT) would induce a protective immunity against O. tsutsugamushi infection. It was particular interest that when mice were infected with O. tsutsugamushi, the bacteria disseminated into the lungs, causing pneumonia. The i.n. vaccination with OMPOT induced IgG responses in serum and bronchoalveolar lavage (BAL) fluid. The anti-O. tsutsugamushi IgA Abs in BAL fluid after the vaccination showed a high correlation of the protection against O. tsutsugamushi. The vaccination induced strong Ag-specific Th1 and Th17 responses in the both spleen and lungs. In conclusion, the current study demonstrated that i.n. vaccination with OMPOT elicited protective immunity against scrub typhus in mouse with O. tsutsugamushi infection causing subsequent pneumonia.
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KEYWORD
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Intranasal administration, Orientia tsutsugamushi, Protective immunity, Pneumonia
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